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Mark McDonnell

Mark McDonnell

Unclaimed
Managing Director, ARCH Venture PartnersARCH Venture PartnersChicago, IL

Current Firm

ARCH Venture Partners

Focus

Biotech, Digital Health

About Mark McDonnell

Mark McDonnell is a Managing Director at ARCH Venture Partners, a leading venture capital firm focused on early-stage scientific innovation. He invests across biotech, digital health, artificial intelligence, and deeptech sectors, identifying transformative technologies poised to create significant impact. At ARCH, McDonnell leverages deep expertise in emerging scientific domains to support founding teams in translating cutting-edge research into scalable businesses. His investment thesis centers on companies addressing fundamental challenges in healthcare and technology through novel scientific approaches. McDonnell is actively involved in sourcing, diligencing, and supporting portfolio companies through their critical early stages. His focus on converging scientific disciplines—from biotechnology to AI—reflects ARCH's commitment to backing the most ambitious technical founders and breakthrough technologies that define the next generation of innovation.

Focus Areas

Investment Stage

Pre-Seed
Seed
Series A
Series B+

Other Investors at ARCH Venture Partners

Clinton Bybee headshot
Clinton Bybee

Co-Founder and Managing Director Emeritus, ARCH Venture Partners

ARCH Venture Partners

Kristina Burow headshot
Kristina Burow

Managing Director, ARCH Venture Partners

ARCH Venture Partners

Paul Berns headshot
Paul Berns

Managing Director, ARCH Venture Partners

ARCH Venture Partners

Robert Nelsen headshot
Robert Nelsen

Co-Founder and Managing Director, ARCH Venture Partners

ARCH Venture Partners

Steve Gillis headshot
Steve Gillis

Managing Director, ARCH Venture Partners

ARCH Venture Partners

View full team →

Investment Profile

Mark McDonnell is a Managing Director, ARCH Venture Partners at ARCH Venture Partners, based in Chicago, IL.

Mark's investment focus spans Biotech, Digital Health, AI, Deeptech, primarily investing at the Seed, Series A stages. This specialization allows for deep domain knowledge and strong network effects that benefit portfolio companies.

Frequently Asked Questions

Who is Mark McDonnell?

Mark McDonnell is a Managing Director, ARCH Venture Partners at ARCH Venture Partners, based in Chicago, IL. Their investment focus includes Biotech, Digital Health, AI.

What does Mark McDonnell invest in?

Mark McDonnell focuses on investments in Biotech, Digital Health, AI, Deeptech through ARCH Venture Partners. These focus areas reflect their domain expertise and the types of startups they actively seek to back.

What firm is Mark McDonnell at?

Mark McDonnell is currently at ARCH Venture Partners, headquartered in Chicago, IL, serving as Managing Director, ARCH Venture Partners.

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