DCVC

DCVC is a San Francisco venture capital firm founded in 2011 by Matt Ocko and Zachary Bogue. It invests in deep-tech companies that apply modern computation, data science and machine learning to industries that have been slow to adopt them, including agriculture, mining and heavy industry, space and earth observation, manufacturing, logistics, computing hardware and life sciences. The firm runs a dedicated biotechnology practice, DCVC Bio, alongside its core deep-tech funds, with separate managing partners for that strategy. Its published team page lists partner-level staff across both practices: two co-founding managing partners, two managing partners for DCVC Bio, five general partners, principals, and a large bench of operating partners who work with portfolio companies on engineering, commercialization and recruiting. DCVC typically leads at seed and Series A and follows into later rounds. Diligence is technical and often computational: the firm looks for companies where a hard scientific or engineering advantage, combined with software and data, produces a defensible position in a large physical market rather than a thin application layer. Portfolio companies include Planet Labs in satellite imaging, Rigetti Computing in quantum computing, Recursion Pharmaceuticals in computational drug discovery, Farmers Business Network in agricultural data, Desktop Metal in additive manufacturing, NotCo in food formulation, and Upside Foods, formerly Memphis Meats, in cultivated meat. Founders should expect long technical diligence, an investor comfortable with capital-intensive and regulated markets, and support aimed at scientific and industrial execution rather than consumer growth. DCVC is most relevant to teams whose core claim is a computational or scientific edge applied to a large, unglamorous industry, and who need a lead investor that can stay through multiple hardware or clinical milestones.