At a Glance
Domain Associates, founded in 1985, stands as one of the most established and successful life sciences venture capital firms in the United States. Based in Princeton, New Jersey, with additional offices in San Diego, the firm has been exclusively focused on healthcare investments for nearly four decades, building deep expertise in biopharmaceuticals, diagnostics, medical devices, and digital health technologies.
The firm has deployed over $4 billion across multiple funds, with a track record that includes early investments in some of the most significant healthcare companies of the past two decades. Notable portfolio successes include Moderna (mRNA therapeutics), Exact Sciences (cancer diagnostics), Foundation Medicine (genomic profiling), and Alnylam Pharmaceuticals (RNAi therapeutics). Domain's investment approach emphasizes working closely with scientific founders and management teams to build category-defining companies that address significant unmet medical needs. The firm's partners combine scientific backgrounds with extensive operational and investment experience, enabling them to support companies through complex development processes from early-stage research through commercialization and public markets.
“Investing in life sciences companies developing transformative therapies, diagnostics, and medical technologies to improve human health.”
Domain Associates primarily invests at the Seed, Series A, Series B+ stages. This means they focus on companies that are building their initial product and finding product-market fit.
Domain Associates is headquartered in San Diego, CA. Many of their portfolio companies are also based in this region, though they invest across geographies.
Domain Associates focuses on investments in Biotech, Digital Health. Their portfolio reflects deep expertise and networks within these sectors.
Domain Associates manages approximately $4B in assets under management (AUM) across their funds.