🤖 AI + San Francisco, CA
Discover 96 venture capital firms investing in AI and headquartered in San Francisco, CA. This directory highlights investors with active ai portfolios and a local presence in San Francisco, CA, helping founders identify the right capital partners for their next raise. Browse firm profiles, compare check sizes and stage focus, and find investors who understand both the ai landscape and the San Francisco, CA startup ecosystem.
96 firms
San Francisco, CA is home to 96+ venture capital firms that specialize in AI. The top firms combine deep AI expertise with local San Francisco, CA networks, deal flow, and industry connections.
Start by reviewing the 96 AI-focused VCs based in San Francisco, CA ranked on this page. Evaluate each firm's stage focus, check size, and portfolio to find the best fit for your startup's needs.
San Francisco, CA has an active AI investment community with firms specializing in this sector. Local investors bring valuable industry connections and ecosystem advantages specific to the San Francisco, CA market.
Venture firm founded by former Twitter CEO Dick Costolo and former Twitter COO Adam Bain, investing in growth-stage companies.
Series B investor acting as venture coaches avoiding board seats
Ex-founder deeptech fund making first checks into non-consensus moonshots
Led by active AI practitioners Socher, Manning, Goldbloom.
Hybrid venture and hedge fund backing brilliant blockchain founders
Seed-stage fund orchestrating targeted introductions to multi-stage funds
Pre-seed and seed venture firm investing in founders building at the intersection of AI, data, and software.
Early-stage venture firm investing in open source, developer tools, and infrastructure software companies.
Early-stage investor with operator-led team maintaining founder relationships.
Seed-stage firm using psychometrics and structured data to archetype founders.
Concentrated high-conviction early-stage bets with flat partnership structure.
Solo GP enabling rapid investment decisions with operator support.
Partners can unilaterally approve investments, uses data-driven outreach.
Global venture firm connecting startups with Fortune 500 corporate partners across US, Europe, Asia, and Africa.
Fund of funds investing in emerging manager micro-VC funds, helping new fund managers get started in venture capital.
Citigroup's corporate venture arm investing in fintech, enterprise technology, and cybersecurity companies globally.
Contrarian n-of-1 investor across frontier sectors.
Venture firm powered by a network of top university students and recent graduates, scouting and investing in the next generation of founders.
AI-native venture firm founded by former Bridgewater and Facebook AI executive Sarah Guo, investing in the AI transformation.
AI-focused venture firm purpose-built for Software 3.0 by Sarah Guo.
AI-native venture firm founded by Sarah Guo, investing exclusively in artificial intelligence companies across infrastructure, applications, and vertical AI.
PayPal Mafia-led with metrics-driven B2B SaaS playbook.
Growth-stage technology investor focused on market-leading companies with durable competitive advantages and large addressable markets.
Early-stage AI startups receive founder-led mentorship and product integration.
Solo-GP investor with unusually high hit rate in breakout companies.
Engineer-first solo GP investing in infra startups at early stages.
Student-founder focused with operating playbooks and community.
Contrarian, founder-maximalist VC backing hard scientific breakthroughs.
Invests in purpose-driven entrepreneurs reinventing industries.
Alphabet-backed AI-focused investor with longer timelines and ex-Google technical partners.
Selective high-conviction firm making concentrated bets to scale.
Early-stage investor in enterprise infrastructure working hands-on from day 0.
Seed-stage venture fund co-founded by former Google and YouTube executives, investing in bottom-up technology companies.
Former YouTube and Twitter product leaders backing early-stage startups.
Early-stage venture fund investing in founders solving problems in work, education, and human capital development.
Early-stage venture firm founded by former AngelList president, investing in seed-stage companies across technology sectors.
Leads early rounds for technically intense AI teams in physical-world domains.
Emerging manager fund focused on seed-stage investments in enterprise software, AI, and developer tools.
Solo GP fund led by former Stripe executive Lachy Groom, investing in early-stage technology companies.
Champion of founders others dismiss, offering devoted partner support.
Evergreen Microsoft venture fund leveraging product teams and co-selling.
Evergreen fund integrated with $10B+ hedge-fund platform.
Microsoft's corporate venture fund investing in enterprise technology startups across AI, security, and cloud infrastructure.
Seed-stage venture firm founded by former Floodgate partner, investing in founder-friendly deals across technology sectors.
Serial founder-led with Signal platform and CEO Guild network.
Early-stage venture firm investing in AI-native companies that transform enterprise operations and decision-making.
College-student focused with non-dilutive grant programs.
Early-stage venture firm (formerly GGV Capital's US arm) focused on backing visionary founders in AI, enterprise, and consumer technology.
First institutional fund exclusively for commercial open-source startups.
Early-stage, multi-thematic firm with purpose-driven focus.
OpenAI's venture arm running Converge program for exceptional AI builders.
Community-driven venture fund composed of over 150 senior tech operators, investing in early-stage B2B companies led by diverse founders.
Active AI builders operating Imbue, training 100B+ models.
World's largest edtech-focused venture firm, investing in companies transforming education and workforce development globally.
Seed-stage led by former Facebook and OpenAI engineers focused on infra.
Pre-seed focused venture firm led by Charles Hudson, investing very early in consumer and enterprise startups.
Early-stage venture firm founded by Alfred Lin's former partner, investing in seed and Series A technology companies.
Deep tech venture firm investing in companies that feel like science fiction today but will define tomorrow.
Data-driven venture firm using a proprietary platform called Beacon that analyzes billions of data points to identify top talent and companies.
Applied AI investor with defensible data moats and recruiting platform.
Fast-moving pre-seed and seed fund investing in technology companies across sectors, known for speed of decision-making.
Community-driven venture fund investing at the earliest stages in founders exploring new frontiers in technology.
Growth-stage fund within Spark Capital, investing in category-leading technology companies at the expansion stage.
Seed-stage investor focused on data-centric, moat-driven startups.
Data-driven venture firm using quantitative product analytics to identify high-growth technology companies, founded by former Social Capital partners.
Long-term partner emphasizing culture, diversity, and founder connections.
Network-driven, geo-agnostic firm with operator-angel distribution.
Early-stage venture firm founded by Ross Fubini, investing in seed-stage technology companies across enterprise and consumer.
Exclusively focused on AI-driven B2B with commercial-AI pattern recognition.
Enterprise software venture firm focused on seed-stage companies building foundational B2B technology.
Iconic early-stage venture firm known for its equal partnership structure and concentrated portfolio approach.
Global venture and growth equity firm with a responsible innovation philosophy, investing from seed to growth.
Early and growth-stage venture capital firm focused on enterprise infrastructure, applied AI, and consumer technology.
A venture fund founded by Dick Costolo and Adam Bain (former Twitter executives). Invests in early-stage consumer and enterprise technology.
Early-stage venture firm investing in technical founders building AI, infrastructure, and applied technology companies.
A venture capital firm investing in transformative software companies at the seed and Series A stage. Focuses on companies creating new categories.
The venture arm of Calm, the meditation and wellness app. Calm Ventures invests in early-stage companies focused on mental health, wellness, and consumer technology that promotes well-being.
Early-stage venture firm founded by David Sacks investing in enterprise software and marketplace companies.
Deep tech venture capital firm focused on AI, machine learning, and computational technologies. Invests in companies leveraging data and computation for breakthrough solutions.
A growth-oriented investment firm that manages capital for ultra-high-net-worth families and institutions. Known for large growth investments and providing strategic guidance to scaling technology companies.
Growth equity firm backed by some of the world's most influential technology founders, investing in market-defining companies.
Founded by Reddit co-founder Alexis Ohanian and Garry Tan (now Y Combinator president). One of the most connected pre-seed and seed firms in Silicon Valley.
Data-driven venture capital firm that uses quantitative analysis to invest in legal technology and litigation finance. They apply machine learning and data science to evaluate legal tech investments and litigation outcomes.
Microsoft's corporate venture fund investing in enterprise-focused startups. Provides portfolio companies with access to Microsoft's global platform and ecosystem.
Solo GP fund focused on investing in AI and automation companies. Takes a thesis-driven approach to identifying startups that are leveraging artificial intelligence to transform traditional industries.
The venture capital and innovation arm of Dentons, the world's largest law firm. They invest in legal technology startups and provide unique access to legal expertise and global client networks.
A Berlin and San Francisco-based micro-VC that invests in early-stage B2B software companies. They focus on enterprise technology startups and provide operational expertise to help founders build scalable businesses.
Salesforce Ventures invests in enterprise software companies, particularly those building on or integrating with the Salesforce platform. They focus on AI, SaaS, and customer experience technologies.
Samsung NEXT is Samsung's innovation arm that invests in early-stage startups across AI, IoT, digital health, and frontier technologies. They provide portfolio companies with access to Samsung's global ecosystem and manufacturing capabilities.
A micro-VC fund that invests in early-stage technology companies with a focus on diverse founders and underrepresented markets. They provide capital and strategic support to help entrepreneurs build successful businesses.
Founded by Sam Lessin and others, known for their eclectic portfolio and contrarian investment approach. Focuses on early-stage companies across various sectors with unique business models.
Founded by Ravi Belani, combines a community of builders with an investment fund. Provides a space for entrepreneurs to explore ideas and offers pre-seed funding to the most promising projects.
A community and fund for technologists and entrepreneurs exploring their next company. Provides pre-seed capital and a community of builders.
A Silicon Valley fund investing in transformative AI, robotics, and space technology companies. Focuses on deep tech with potential for paradigm-shifting impact.
Founded by Ryan Hoover, invests in very early-stage startups often at the idea or prototype stage. Known for quick decisions and supporting solo founders and weekend projects that become companies.
The growth-stage fund of Y Combinator, providing follow-on capital to the accelerator's best-performing companies at Series B and beyond.