Enterprise Venture Capital Firms in San Francisco, CA

Venture firm founded by former Twitter CEO Dick Costolo and former Twitter COO Adam Bain, investing in growth-stage companies.

Series B investor acting as venture coaches avoiding board seats

Invests at extreme inception; favors non-traditional founders.

Global accelerator and seed fund investing across 80+ countries.

Early-stage venture firm investing in open source, developer tools, and infrastructure software companies.

Early-stage investor with operator-led team maintaining founder relationships.

World's largest Black-led VC for Real Economy companies.

Seed-stage firm using psychometrics and structured data to archetype founders.

Early-stage fintech investors composed entirely of ex-fintech founders/operators.

Partners can unilaterally approve investments, uses data-driven outreach.

Relationship-driven firm backing founders in capital-intensive frontier areas.

Fund of funds investing in emerging manager micro-VC funds, helping new fund managers get started in venture capital.

Cleantech cycles expert backing hardware+software climate solutions.

Venture firm powered by a network of top university students and recent graduates, scouting and investing in the next generation of founders.

AI-native venture firm founded by former Bridgewater and Facebook AI executive Sarah Guo, investing in the AI transformation.

AI-native venture firm founded by Sarah Guo, investing exclusively in artificial intelligence companies across infrastructure, applications, and vertical AI.

PayPal Mafia-led with metrics-driven B2B SaaS playbook.

Growth-stage technology investor focused on market-leading companies with durable competitive advantages and large addressable markets.

Solo-GP investor with unusually high hit rate in breakout companies.

Student-founder focused with operating playbooks and community.

Consumer technology and enterprise consumerization specialist.

Serial founder seed investor with CFO-grade operational support.

Alphabet-backed AI-focused investor with longer timelines and ex-Google technical partners.

Selective high-conviction firm making concentrated bets to scale.

Private technology-focused investment firm making concentrated bets in high-conviction growth companies worldwide.

AngelList syndicate hunter with craftsman mentality.

Early-stage investor in enterprise infrastructure working hands-on from day 0.

Former YouTube and Twitter product leaders backing early-stage startups.

Early-stage venture fund investing in founders solving problems in work, education, and human capital development.

Pre-seed venture fund led by Elizabeth Yin and Eric Bahn, investing in fast-moving founders across sectors globally.

Transatlantic partnership with Europe-to-US expansion playbooks.

Operator-heavy seed investor with product and recruiting support.

Emerging manager fund focused on seed-stage investments in enterprise software, AI, and developer tools.

Solo GP fund led by former Stripe executive Lachy Groom, investing in early-stage technology companies.

Evergreen Microsoft venture fund leveraging product teams and co-selling.

Microsoft's corporate venture fund investing in enterprise technology startups across AI, security, and cloud infrastructure.

Seed-stage venture firm founded by former Floodgate partner, investing in founder-friendly deals across technology sectors.

Early-stage venture firm investing in AI-native companies that transform enterprise operations and decision-making.

College-student focused with non-dilutive grant programs.

Early-stage venture firm (formerly GGV Capital's US arm) focused on backing visionary founders in AI, enterprise, and consumer technology.

First institutional fund exclusively for commercial open-source startups.

Early-stage venture firm investing in companies building a more sustainable and equitable future through technology.

Community-driven venture fund composed of over 150 senior tech operators, investing in early-stage B2B companies led by diverse founders.

Active AI builders operating Imbue, training 100B+ models.

Seed-stage led by former Facebook and OpenAI engineers focused on infra.

Leading crypto-native investment firm managing hedge fund and venture strategies focused on blockchain protocols and Web3 infrastructure.

Pre-seed focused venture firm led by Charles Hudson, investing very early in consumer and enterprise startups.

Fintech venture firm backed by BBVA, investing in companies transforming financial services through technology.

Early-stage venture firm founded by Alfred Lin's former partner, investing in seed and Series A technology companies.

Data-driven venture firm using a proprietary platform called Beacon that analyzes billions of data points to identify top talent and companies.

Fast-moving pre-seed and seed fund investing in technology companies across sectors, known for speed of decision-making.

Growth-stage fund within Spark Capital, investing in category-leading technology companies at the expansion stage.

San Francisco-based venture firm investing in enterprise software and fintech companies across the US and Europe.

Seed-stage micro-VC offering hands-on, bespoke plans for each company.

Network-driven, geo-agnostic firm with operator-angel distribution.

Climate and industrial technology focused seed-stage venture firm investing in the physical economy's digital transformation.

Physics-inspired framework with Palantir-associated companies.

Early-stage venture firm founded by Ross Fubini, investing in seed-stage technology companies across enterprise and consumer.

Exclusively focused on AI-driven B2B with commercial-AI pattern recognition.

Enterprise software venture firm focused on seed-stage companies building foundational B2B technology.

Iconic early-stage venture firm known for its equal partnership structure and concentrated portfolio approach.

Early-stage venture firm investing in technical founders building AI, infrastructure, and applied technology companies.

A venture capital firm investing in transformative software companies at the seed and Series A stage. Focuses on companies creating new categories.

One of the oldest and most established VC firms in America, founded in 1911. Portfolio includes LinkedIn, Shopify, Twilio, and Pinterest.

A venture firm investing in transformative enterprise software companies. Focuses on companies with strong unit economics and clear paths to profitability.

A growth-oriented investment firm that manages capital for ultra-high-net-worth families and institutions. Known for large growth investments and providing strategic guidance to scaling technology companies.

Growth equity firm backed by some of the world's most influential technology founders, investing in market-defining companies.

Data-driven venture capital firm that uses quantitative analysis to invest in legal technology and litigation finance. They apply machine learning and data science to evaluate legal tech investments and litigation outcomes.

Microsoft's corporate venture fund investing in enterprise-focused startups. Provides portfolio companies with access to Microsoft's global platform and ecosystem.

Solo GP fund focused on investing in AI and automation companies. Takes a thesis-driven approach to identifying startups that are leveraging artificial intelligence to transform traditional industries.

Matrix Partners is a venture capital firm that partners with exceptional entrepreneurs to build transformative technology companies. They focus on enterprise software, consumer internet, and fintech investments from seed to growth stages.

Early-stage venture capital fund investing in Latino founders and companies serving Latino communities across the Americas. Founded by Marianne Hudson to address the Latino funding gap in venture capital.

The venture capital and innovation arm of Dentons, the world's largest law firm. They invest in legal technology startups and provide unique access to legal expertise and global client networks.

A Berlin and San Francisco-based micro-VC that invests in early-stage B2B software companies. They focus on enterprise technology startups and provide operational expertise to help founders build scalable businesses.

Salesforce Ventures invests in enterprise software companies, particularly those building on or integrating with the Salesforce platform. They focus on AI, SaaS, and customer experience technologies.

A micro-VC fund that invests in early-stage technology companies with a focus on diverse founders and underrepresented markets. They provide capital and strategic support to help entrepreneurs build successful businesses.

Founded by Sam Lessin and others, known for their eclectic portfolio and contrarian investment approach. Focuses on early-stage companies across various sectors with unique business models.

A community and fund for technologists and entrepreneurs exploring their next company. Provides pre-seed capital and a community of builders.

A seed-stage venture capital firm that invests in category-creating companies led by exceptional entrepreneurs. They focus on enterprise software, fintech, and healthcare technology with a data-driven investment approach.

Global private equity and venture capital firm with over $120 billion of assets under management. TPG Growth focuses on investments in high-growth companies across technology, healthcare, financial services, and consumer sectors.

A data-driven venture firm founded by former Social Capital partners. Uses quantitative analysis to evaluate product-market fit and growth trajectories.

Version One Ventures is an early-stage venture capital firm that invests in transformative technology companies across North America. They focus on B2B software, fintech, and infrastructure investments with strong product-market fit indicators.

The growth-stage fund of Y Combinator, providing follow-on capital to the accelerator's best-performing companies at Series B and beyond.